The Expressions of NGF and BDNF in the Rats with Intracerebral Hemorrhage

Objective To observe the expression on distribution of NGF and BDNF in rat brain with intracerebral hemorrhage,in order to explore the fuction of the neurotrophic factors against intracerebral hemorrhage injury. Methods Adult male Sprague-Dawle rats were randomly seperated into three groups:normal group,sham operation group,intracerebral hemorrhage group,then the model of intracerebral hemorrhage(ICH) was established in rats by intracerebral injection with autogenous blood. The protein expression of BDNF and NGF was detected by immunohisto-chemistry at 3,6,12,24,48,72h,7d after intracerebral hemorrhage. Results The NGF expression was found increasing in the perienchyma at 6h and BDNF expression increasing in 12h,both peaking at 24h after hemorrhage. Comparing with normal group and sham operation group,the increases of the indexes of BDNF and NGF were statistically signifi cant(P0.05). Conclusion The expression of NGF and BDNF increases as the inducement in the brain of rats after intracerebral hemorrhage,and it is benefi cial for the protection and repair of brain neurons.