The Relationship between Serum HBeAg,HBV DNA and Liver Pathological Change in Chronic Hepatitis B Virus Carriers with Slight Unusual Liver Function

Objective To explore the relationship between serum HBeAg,the qualification of HBV DNA and the histopathologic change of livers in chronic hepatitis B virus carriers with slight unusual liver function.Methods Liver biopsy,serum and serological examination were performed in 90 randomly selected chronic hepatitis B virus carriers with slight unusual liver function.Groups were divided basedon serum HBeAg and HBV DNA levels.Comparisons of liver inflammation and fibrosis stages were conducted between groups.Results All of the 90 subjects had liver injury.Eight cirrhosis,among 83 patients 27 had G≥2,25 had S≥2.The inflammation and fibrosis stages in HBeAg negative group were more severe than HBeAg positive group.No significant differences were observed in the inflammation and fibrosis stages among different HBV DNA levels.Conclusion The chronic HBV carriers with slight unusual liver function all have pathologically liver injuries.SerumHBeAg and HBV DNA are unable to reflect the real condition of liver injury.