The relationship between serum HBeAg,HBV DNA and liver pathological change in chronic hepatitis B virus carriers

Objective:To explore the relationship between serum HBeAg,the qualification of HBV DNA and the histopathologic change of livers in chronic hepatitis B virus carriers with normal liver function.Methods:Liver biopsy,serum and serological examination were performed in 101 randomly selected chronic hepatitis B virus carriers with normal 1iver function.Groups were divided based on serum HBeAg and HBV DNA levels.Comparisons of liver inflammation and fibrosis stages were conducted between groups.Results:83.2%(84/101) subjects had liver injury,62(61.40%) slight CHB,11(10.90%) moderate CHB,and 7 (6.93%) severe CHB,4 (3.96%) cirrhosis.The inflammation and fibrosis stages in HBeAg negative group were more severe than HBeAg positive group(P0.05 or P0.01).The fibrosis stages observed in HBV DNA negative groups were more severe than HBV DNA positive groups(P0.01).Conclusion:HBeAg and HBV DNA are unable to reflect the real condition of liver injury for the chronic HBV carriers.Therefore,hepatic pathological examination should be recommended in the chronic HBV carriers,which contributes to the understanding of disease state and selection of treatment regimen.