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The Expression and Clinical Significance of p53 and Prol iferating Cell Nuclear Antigen (PCNA) in Lung Squamous Cell Carcinoma

Jian Zhu, Min Li, Xu Lang, Mingqiu Liu

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Abstract

Objective To study the relationship between the expression of p53 and proliferating cell nuclear antigen (PCNA) in lung squamous cell carcinoma and clinicpathological features.Methods The expression of p53 and PCNA were detected in 36 cases of lung squamous cell carcinoma and 10 cases of normal lung tissues by SP immunohistochemistry.Results The positive rates of p53 and PCNA was 58.3 %(21/36) and 91.7 %(33/36) respectively. The positive rates of p53 and PCNA were correlated with histological grades,dimensions and lymph node metastasis. The differences were significant( P 0.05 ). The positive rates between p53 and PCNA were associated ( P 0.05 ).Conclusion The detection of p53 and PCNA is valuable for evaluating the malignancy degree and lymph node metastasis of lung squamous cell carcinoma.

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What this paper is about

Objective To study the relationship between the expression of p53 and proliferating cell nuclear antigen (PCNA) in lung squamous cell carcinoma and clinicpathological features.Methods The expression of p53 and PCNA were detected in 36 cases of lung squamous cell carcinoma and 10 cases of normal lung tissues by SP immunohistochemistry.Results The positive rates of p53 and PCNA was 58.3 %(21/36) and 91.7 %(33/36) respectively. The positive rates of p53 and PCNA were correlated with histological grades,dimensions and lymph node metastasis. The differences were significant( P 0.05 ). The positive rates between p53 and PCNA were associated ( P 0.05 ).Conclusion The detection of p53 and PCNA is valuable for evaluating the malignancy degree and lymph node metastasis of lung squamous cell carcinoma.

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Available abstract

Objective To study the relationship between the expression of p53 and proliferating cell nuclear antigen (PCNA) in lung squamous cell carcinoma and clinicpathological features.Methods The expression of p53 and PCNA were detected in 36 cases of lung squamous cell carcinoma and 10 cases of normal lung tissues by SP immunohistochemistry.Results The positive rates of p53 and PCNA was 58.3 %(21/36) and 91.7 %(33/36) respectively. The positive rates of p53 and PCNA were correlated with histological grades,dimensions and lymph node metastasis. The differences were significant( P 0.05 ). The positive rates between p53 and PCNA were associated ( P 0.05 ).Conclusion The detection of p53 and PCNA is valuable for evaluating the malignancy degree and lymph node metastasis of lung squamous cell carcinoma.

Key concepts: Proliferating cell nuclear antigen, Immunohistochemistry, Malignancy, Pathology, Cell, Squamous-cell carcinoma of the lung, Lung, Carcinoma

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The Expression and Clinical Significance of p53 and Prol iferating Cell Nuclear Antigen (PCNA) in Lung Squamous Cell Carcinoma — Research Paper | ScholarLens