2010•The Journal of Medical Theory and PracticeRequires access

The Expression and Clinical Significance of p53 and Proliferating Cell Nuclear Antigen in Non-small Cell Lung Carcinoma

XU Hailin

Abstract

Objective:To investigate the expression and significance of p53 and proliferating cell nuclear antigen(PCNA) in non-small cell lung carcinoma(NSCLC).Methods:The expression of p53 and PCNA were detected in 72 cases of NSCLC and 10 cases of normal lung tissues by SP immunohistochemistry.Results:The positive rates of p53 and PCNA were 58.3 %(42/72)and 91.7%(66/72)respectively.The positive rates of p53 and PCNA were correlated with histological grades,dimensions and lymph node metastasis.The differences were significant(P0.05).The positive rates between p53 and PCNA were associated(P0.05).Conclusion:The abnormal expression of p53 and PCNA may be involved in the carcinogens process of lung cancer and correlated with differentiation grades and lymph node metastasis.

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Key concepts: Proliferating cell nuclear antigen, Immunohistochemistry, Medicine, Lung cancer, Pathology, Antigen, Lymph node, Clinical significance