2011•Chinese Journal of Practical Nervous DiseasesRequires access
Effect of Ginkgo biloba on the expression of GFAP and the apoptosis cells after the cerebral ischemia and reperfusion in rats
Duan Zhoufang, Jinlan Wang, Lou Ji-yu, Yifeng Liu, Qing Li, Meixia He
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Abstract
目的 研究银杏叶提取物(EGb761)对大鼠局灶性脑缺血再灌注后神经细胞凋亡和星形胶质细胞表达的变化.方法 雄性SD大鼠随机分为假手术组、单纯缺血组、EGb761干预组,线栓法建立大脑中动脉缺血再灌注模型(MCAO),原位末端标记(TUNEL)法观察神经细胞的凋亡情况,免疫组化法观测星形胶质细胞的表达.结果 与单纯缺血组相比EGb761干预组GFAP、细胞凋亡数目明显降低,且差别有统计学意义(P＜...