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Effect of EGB on GFAP in focal cerebral ischemia/reperfusion injury rats

Yuan De-xi

Abstract

Objective To observe the effect of extract of Ginkgo Biloba on expression of GFAP of astrocyte in focal cerebral ischemia/reperfusion injury rats. Methods Rat middle cerebral ischemia/reperfusion(I/R) injury model was established with suture emboli method. The expression of GFAP was investigated by immunohistochemical method and analyzed by Metamoph analysis system. Neural functional deficiency was observed in 24 h, 48 h, 72 h 96 h after cerebralischemio/reperfusion, differerent time. Results The neural functional score was better in EGB group than in I/R group. The expression of GFAP was observed 24h after cerebral ischemia, reached a maximum at 72h in I/Rgroups. The expressions of GFAP in EGB groups were decreased. Conclusion The expression of GFAP is increased after focal cerebral I/R injury. EGB could inhibit the high expression of GFAP in actived astrocytes and alleviates the focal cerebral I/R injury in rats.

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Key concepts: Ischemia, Astrocyte, Immunohistochemistry, Reperfusion injury, Medicine, Glial fibrillary acidic protein, Anesthesia, Pathology