2008•Heilongjiang yiyao kexueRequires access

Effect of Ginkgo biloba extract on glial fibrillary acidic protein in focal cerebral ischemia/reperfusion injury rats

Yuan De-xin

Abstract

Objective:To observe the effects of the extract of Ginkgo Biloba(EGB) on the expression of glial fibrillary acidic protein(GFAP) of the astrocyte in focal cerebral ischemia/reperfusion injury rats.Methods:A rat middle cerebral ischemia/reperfusion(I/R) injury model was established by using the suture emboli method.The GFAP expression was analyzed by Metamoph analysis system and the neural functional damage in differerent times was observed.Results:The recovery of the neural functional damage was better in EGB group than that in I/R group.The GFAP expression was found at 24h after reperfusion and at 2h after ischemia,reaching a maximum of 72h in I/R groups.EGB could inhibit high expression of GFAP in EGB groups.Conclusion:EGB has inhibitory action on activated astrocytes,which may be one of mechanisms to protect neurons.

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Key concepts: Glial fibrillary acidic protein, Ginkgo biloba, Astrocyte, Ischemia, Reperfusion injury, Pharmacology, Chemistry, Protein expression