2018•Bioorganic ChemistryRequires access

Synthesis and biological evaluation of some N-(3-(1H-tetrazol-5-yl) phenyl)acetamide derivatives as novel non-carboxylic PTP1B inhibitors designed through bioisosteric modulation

Neelesh Maheshwari, Chandrabose Karthikeyan, Shraddha V. Bhadada, Chandan Sahi, Amit Kumar Verma, N. S. Hari Narayana Moorthy, Piyush Trivedi

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Key concepts: Acetamide, Chemistry, Tetrazole, Lead compound, Stereochemistry, Docking (animal), IC50, Carboxylic acid

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Synthesis and biological evaluation of some N-(3-(1H-tetrazol-5-yl) phenyl)acetamide derivatives as novel non-carboxylic PTP1B inhibitors designed through bioisosteric modulation — Research Paper | ScholarLens