2022•Bioorganic ChemistryRequires access

Lead optimization and biological evaluation of diazenylbenzenesulfonamides inhibitors against glyoxalase-I enzyme as potential anticancer agents

Buthina Abdallah Al-Oudat, Nizar A. Al‐Shar’i, Qosay Ali Al-Balas, Suaad Abdallah Audat, Mohammad A. Y. Alqudah, Ali H. Hamzah, Ramez W. Hallak, Mel F. Bedi, Amanda C. Bryant-Friedrich

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Key concepts: Chemistry, Lead compound, IC50, Enzyme, Active site, Docking (animal), Stereochemistry, Biochemistry