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Free radical scavenging and lipid peroxidation of Thai medicinal plants used for diabetic treatment.

Lerluck Steinrut, Arunporn Itharat, Srisopa Ruangnoo

Abstract

OBJECTIVE: To investigate antioxidant activities of some selected plants used to treat diabetic patients by Thai folk doctors. MATERIAL AND METHOD: Ten Thai plants were selected, macerated and extracted with 95% ethanol. DPPH scavenging and lipid peroxidation assays were used to test the antioxidant activities of the extracts. RESULTS: Mammea siamensis (Saaraphee), Tacca chantrieri (Narapusri) and Albizia myriophylla (Cha Em Thai) showed the highest antioxidant activity on DPPH radical assay (EC50 = 10.17, 10.24 and 14.45 microg/ml, respectively). Mimussops elengi (Pikun), M. siamensis (Saaraphee) and A. myriophylla (Cha Em Thai) exhibited the highest antioxidant activity by lipid peroxidation assay (IC50 0.39, 0.43 and 0.70 microg/ml, respectively). Six often plant extracts showed antioxidant activity on both assays (IC50 < 20 microg/ml). CONCLUSION: These plant extracts containing in Thai folklore antidiabetic medicine, which showed high antioxidant activity, may be used effectively for the treatment of diabetic patients.

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Key concepts: DPPH, Antioxidant, Lipid peroxidation, Traditional medicine, Medicine, EC50, IC50, Medicinal plants