2017•Bioorganic & Medicinal Chemistry LettersOpen access

Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV

Mark J. Mitton‐Fry, Steven J. Brickner, Judith C. Hamel, Rose A. Barham, LORI BRENNAN, Jeffrey M. Casavant, Xiaoyuan Ding, Steven M. Finegan, Joel R. Hardink, Thủy Hoàng, Michael D. Huband, Meghan Maloney, Anthony Marfat, Sandra P. McCurdy, Dale McLeod, Chakrapani Subramanyam, Michael A. Plotkin, Usa Datta Reilly, John R. Schafer, Gregory G. Stone, Daniel P. Uccello, Todd A. Wisialowski, Kwansik Yoon, Richard P. Zaniewski, Christopher Zook

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Key concepts: DNA gyrase, Topoisomerase, Topoisomerase IV, Chemistry, hERG, In vivo, Antibacterial activity, Antibacterial agent