2011•European Journal of Medicinal ChemistryRequires access

Synthesis and structure–activity relationship studies of 4-arylthiosemicarbazides as topoisomerase IV inhibitors with Gram-positive antibacterial activity. Search for molecular basis of antibacterial activity of thiosemicarbazides

Agata Siwek, Paweł Stączek, Joanna Stefańska

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Key concepts: DNA gyrase, Topoisomerase, Chemistry, Antibacterial activity, Topoisomerase IV, Stereochemistry, Biological activity, Structure–activity relationship

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Synthesis and structure–activity relationship studies of 4-arylthiosemicarbazides as topoisomerase IV inhibitors with Gram-positive antibacterial activity. Search for molecular basis of antibacterial activity of thiosemicarbazides — Research Paper | ScholarLens