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2008•Analytical chemistry, an Indian journalRequires access

A validated RP-HPLC method for simultaneous estimation of ofloxacin and satranidazole from tablets

A. Sanjay A. Sanjay, K. Vinitha Prakash, Sutar Ravindra, Syad N.Lateef, Rahul Keshav Godge

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Abstract

A simple, selective, rapid, precise and accurate reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of ofloxacin and satranidazole in combined tablet dosage form. The method was carried out on Jasco HPLC system with HiQ Sil C18Wcolumn (250i‚´4.6mm i.d.), usingAcetonitrile:Ammonium acetate 65:35v/v as a mobile phase. The detectionwas carried out usingUV detector set at 305nm. Clonazepamwas used as internal standard. BeerÂ’s law is obeyed in the concentration range of 2.0 to 20.0i­g mL-1 and 3.0 to 30i­g mL-1 of Ofloxacin and Satranidazole, respectively. The method has been successfully applied for the analysis of drugs in pharmaceutical formulations. Results of analysis were validated statistically and by recovery studies.

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What this paper is about

A simple, selective, rapid, precise and accurate reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of ofloxacin and satranidazole in combined tablet dosage form. The method was carried out on Jasco HPLC system with HiQ Sil C18Wcolumn (250i‚´4.6mm i.d.), usingAcetonitrile:Ammonium acetate 65:35v/v as a mobile phase. The detectionwas carried out usingUV detector set at 305nm. Clonazepamwas used as internal standard. BeerÂ’s law is obeyed in the concentration range of 2.0 to 20.0i­g mL-1 and 3.0 to 30i­g mL-1 of Ofloxacin and Satranidazole, respectively. The method has been successfully applied for the analysis of drugs in pharmaceutical formulations. Results of analysis were validated statistically and by recovery studies.

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Available abstract

A simple, selective, rapid, precise and accurate reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of ofloxacin and satranidazole in combined tablet dosage form. The method was carried out on Jasco HPLC system with HiQ Sil C18Wcolumn (250i‚´4.6mm i.d.), usingAcetonitrile:Ammonium acetate 65:35v/v as a mobile phase. The detectionwas carried out usingUV detector set at 305nm. Clonazepamwas used as internal standard. BeerÂ’s law is obeyed in the concentration range of 2.0 to 20.0i­g mL-1 and 3.0 to 30i­g mL-1 of Ofloxacin and Satranidazole, respectively. The method has been successfully applied for the analysis of drugs in pharmaceutical formulations. Results of analysis were validated statistically and by recovery studies.

Key concepts: Ofloxacin, Chromatography, Ammonium acetate, High-performance liquid chromatography, Chemistry, Pharmaceutical formulation, Materials science, Biochemistry

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