ScholarLens Back to search
2010•Chinese Veterinary ScienceRequires access

Studies of pharmacokinetics of cefquinome in boar.

Zhang ChiYe, Yu JunJun, Yu DaiPeng, Yahong Liu

Open publisher page 0 citations

Abstract

The pharmacokinetics parameters were investigated following the single intravenous injection(2mg/kg of dosage) of cefquinome in 5 healthy boars,and compared to the parameters of cefquinome in healthy swine.The concentrations of cefquinome in plasma were determined by RP-HPLC,and the concentration-time data was analyzed with WinNonlin program.It was best to fit the cefquinome concentration-time data to two-compartment open model after the single intravenous injection.The main pharmacokine-tics parameters were as follows:t1/2α=0.22h±0.05h,t1/2β=1.65h±0.46h,CL=0.29L/(h·kg)± 0.061L/(h·kg),AUC=7.2h·mg/L±1.49h·mg/L,Vss=0.59L/kg±0.66L/kg,MRT=2.16h±0.65h.The above-mentioned means were not different(P0.05) from that in the healthy swine.

About this research paper

What this paper is about

The pharmacokinetics parameters were investigated following the single intravenous injection(2mg/kg of dosage) of cefquinome in 5 healthy boars,and compared to the parameters of cefquinome in healthy swine.The concentrations of cefquinome in plasma were determined by RP-HPLC,and the concentration-time data was analyzed with WinNonlin program.It was best to fit the cefquinome concentration-time data to two-compartment open model after the single intravenous injection.The main pharmacokine-tics parameters were as follows:t1/2α=0.22h±0.05h,t1/2β=1.65h±0.46h,CL=0.29L/(h·kg)± 0.061L/(h·kg),AUC=7.2h·mg/L±1.49h·mg/L,Vss=0.59L/kg±0.66L/kg,MRT=2.16h±0.65h.The above-mentioned means were not different(P0.05) from that in the healthy swine.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The pharmacokinetics parameters were investigated following the single intravenous injection(2mg/kg of dosage) of cefquinome in 5 healthy boars,and compared to the parameters of cefquinome in healthy swine.The concentrations of cefquinome in plasma were determined by RP-HPLC,and the concentration-time data was analyzed with WinNonlin program.It was best to fit the cefquinome concentration-time data to two-compartment open model after the single intravenous injection.The main pharmacokine-tics parameters were as follows:t1/2α=0.22h±0.05h,t1/2β=1.65h±0.46h,CL=0.29L/(h·kg)± 0.061L/(h·kg),AUC=7.2h·mg/L±1.49h·mg/L,Vss=0.59L/kg±0.66L/kg,MRT=2.16h±0.65h.The above-mentioned means were not different(P0.05) from that in the healthy swine.

Key concepts: Pharmacokinetics, Plasma concentration, High-performance liquid chromatography, Chromatography, Animal science, Biology, Veterinary medicine, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Studies of pharmacokinetics of cefquinome in boar. — Research Paper | ScholarLens