Pharmacokinetics and Bioequivalence Evaluation of Cefquinome Sulfate Injection in Pigs

To evaluate the pharmacokinetics and bioequivalence of cefquinome sulfate injection in pigs,10 healthy pigs were randomly divided into two groups and given two kinds of cefquinome sulfate injection by intramuscular injection(2 mg/kg).The high performance liquid chromatography method was used to detect the concentration of cefquinome sulfate in plasma,and the major pharmacokinetic parameters were analyzed and the bioequivalence of two formulations was evaluated.The eliminate half life(T1/2β),peak concentration(Cmax) and area under curve(AUC) of the two groups after given two kinds of cefquinome sulfate injection had no significant difference.Based on analysis of two-sided t-test,the 90% confidential intervals of the tested cefquinome sulfate injection in AUC were 108.2%~115.3% and were within the range(80%~120%) of the reference injection,the 90% confidential intervals in Cmax were 91.9%~115.3% and were within the range(70%~130%) of the reference injection.The two products were bioequivalent and had similar pharmacokinetics in healthy pigs,providing theoretical basis for making of clinical dosage regimen and clinical rational administration.