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Effects of Ethanol Bulb-extract of Allium sativum on Serum Transaminase and Alkaline Phosphatase Activities in Albino Rats

D. Nkasi, U. Alum Esther

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Abstract

The effects of ethanol bulb-extract of Allium sativum on serum transaminase and alkaline phosphatase activities were investigated on twenty male albino rats using spectrophotometric methods. The extract from Allium sativum was extracted with soxhlet apparatus in the presence of ethanol at 46°C. The rats were divided into four groups: A, B, C and D. Animals in groups A, B, C and D received the extract at the doses of 200mg/kg, 400mg/kg, 600mg/kg and 0mg/kg body weights respectively for two weeks by oral intubation. The rats in groups A, B and C had significant (p<0.05) elevations in body weights. The activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) were significantly (p<0.05) reduced, hence the extract of Allium sativum could be hepato-protective.

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What this paper is about

The effects of ethanol bulb-extract of Allium sativum on serum transaminase and alkaline phosphatase activities were investigated on twenty male albino rats using spectrophotometric methods. The extract from Allium sativum was extracted with soxhlet apparatus in the presence of ethanol at 46°C. The rats were divided into four groups: A, B, C and D. Animals in groups A, B, C and D received the extract at the doses of 200mg/kg, 400mg/kg, 600mg/kg and 0mg/kg body weights respectively for two weeks by oral intubation. The rats in groups A, B and C had significant (p<0.05) elevations in body weights. The activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) were significantly (p<0.05) reduced, hence the extract of Allium sativum could be hepato-protective.

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Available abstract

The effects of ethanol bulb-extract of Allium sativum on serum transaminase and alkaline phosphatase activities were investigated on twenty male albino rats using spectrophotometric methods. The extract from Allium sativum was extracted with soxhlet apparatus in the presence of ethanol at 46°C. The rats were divided into four groups: A, B, C and D. Animals in groups A, B, C and D received the extract at the doses of 200mg/kg, 400mg/kg, 600mg/kg and 0mg/kg body weights respectively for two weeks by oral intubation. The rats in groups A, B and C had significant (p<0.05) elevations in body weights. The activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) were significantly (p<0.05) reduced, hence the extract of Allium sativum could be hepato-protective.

Key concepts: Allium sativum, Alkaline phosphatase, Bulb, Aspartate transaminase, Alanine transaminase, Chemistry, Transaminase, Ethanol

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Effects of Ethanol Bulb-extract of Allium sativum on Serum Transaminase and Alkaline Phosphatase Activities in Albino Rats — Research Paper | ScholarLens