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[The inhibitive effects of the ethanol extract from Radix et Rhizoma Rhei on the secretion of HBsAg and HBeAg].

Ni Liu, Bianxian Zhu, Huang Zhengchang, Yu-Tong Zhu, Qiaoyan Chen, Xing-Bo Guo, Guoqiao Li

Abstract

OBJECTIVE: To study the anti-HBV effects of the ethanol extract from Radix et Rhizoma Rhei. METHODS: The influence of the ethanol extract from Radix et Rhizoma Rhei on the secretion of HBeAg and HBsAg was observed through the culture of the 2.2.15 cell with the ethanol extract. RESULTS: 11 days after the ethanol extract's action on the 2.2.15 cell, its 50% concentration dose (CD50) is 39.69 g/L; inhibiting dose (ID50) to HBsAg and HBeAg are 3.29 g/L and 2.34 g/L respectively, and TI 12.06 and 16.96 respectively. CONCLUSION: The ethanol extract from Radix et Rhizoma Rhei can markedly inhibit the secretion of HBsAg and HBeAg in 2.2.25 cell lines.

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Key concepts: HBsAg, HBeAg, Radix (gastropod), Ethanol, Secretion, Chemistry, Traditional medicine, Pharmacology