2001•PubMedRequires access
[The expression of p53, cyclin D1 and PCNA in non-small cell lung cancer].
X Wang, Li Y, Hai Zhao, Tongwei Zhao, N Zhang, Yuyan Ma, Jinfeng Yang
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Abstract
BACKGROUND: To study the expression of p53, cyclin D1 proteins and their relations to cell proliferation in non-small cell lung cancer ( NSCLC) . METHODS: The expression of p53, cyclin D1 proteins and PCNA was studied in 74 cases of NSCLC and 10 cases of normal lung tissues by SP immunohistochemical technique. RESULTS: Positive rates of p53 and cyclin D1 protein expression in NSCLC were 55. 41% and 37. 84% respectively, which were both significantly higher than those in normal lung tissues ( P₁ = 0. 003 1, P₂= 0. 042 9) . p53 protein expression correlated remarkably with lymphatic metastasis ( P= 0. 022 2) . p53 and cyclin D1 protein expression correlated significantly with PCNA index respectively ( P₁ = 0. 001 0, P₂ = 0. 000 9) . There was no significant correlation between p53 and cyclin D1 proteins ( P > 0. 05) . CONCLUSIONS: p53, cyclin D1 protein overexpression plays an important role in tumorigenesis and cell proliferation of NSCLC. p53 is also an important indicator in the diagnosis and prognostic evaluation of NSCLC.