ScholarLens Back to search
2000•PubMedRequires access

[Evaluation of red cell mean corpuscular volume and simple tube red cell osmotic fragility quantitative test in detection of thalassemia].

J Deng, Yang Liu, Liu Y

Open publisher page 2 citations

Abstract

OBJECTIVE: To evaluate and compare the detection efficiency of red cell mean corpuscular volume(MCV) test against simple tube red cell osmotic fragility quantitative test(STROFQT) in diagnosis of thalassemia. METHODS: 1978 subjects (989 couples) were detected by both MCV test and STROFQT, 158 samples from subjects were tested by alpha,beta-thalassemia DNA polymerase chain reaction(PCR) and serum ferritin test. RESULTS: The positive rate (9.0%), sensitivity (98.9%) of MCV test were higher than those of STROFQT (8.1%, 88.6%) (P < 0.05). The specificity of MCV test showed no statistic significance compared with that of STROFQT (P > 0.05). CONCLUSION: Both MCV test and STROFQT served as helpful approaches in detection of thalassemia, MCV test shows better diagnostic efficiency for screening than STROFQT.

About this research paper

What this paper is about

OBJECTIVE: To evaluate and compare the detection efficiency of red cell mean corpuscular volume(MCV) test against simple tube red cell osmotic fragility quantitative test(STROFQT) in diagnosis of thalassemia. METHODS: 1978 subjects (989 couples) were detected by both MCV test and STROFQT, 158 samples from subjects were tested by alpha,beta-thalassemia DNA polymerase chain reaction(PCR) and serum ferritin test. RESULTS: The positive rate (9.0%), sensitivity (98.9%) of MCV test were higher than those of STROFQT (8.1%, 88.6%) (P < 0.05). The specificity of MCV test showed no statistic significance compared with that of STROFQT (P > 0.05). CONCLUSION: Both MCV test and STROFQT served as helpful approaches in detection of thalassemia, MCV test shows better diagnostic efficiency for screening than STROFQT.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE: To evaluate and compare the detection efficiency of red cell mean corpuscular volume(MCV) test against simple tube red cell osmotic fragility quantitative test(STROFQT) in diagnosis of thalassemia. METHODS: 1978 subjects (989 couples) were detected by both MCV test and STROFQT, 158 samples from subjects were tested by alpha,beta-thalassemia DNA polymerase chain reaction(PCR) and serum ferritin test. RESULTS: The positive rate (9.0%), sensitivity (98.9%) of MCV test were higher than those of STROFQT (8.1%, 88.6%) (P < 0.05). The specificity of MCV test showed no statistic significance compared with that of STROFQT (P > 0.05). CONCLUSION: Both MCV test and STROFQT served as helpful approaches in detection of thalassemia, MCV test shows better diagnostic efficiency for screening than STROFQT.

Key concepts: Mean corpuscular volume, Erythrocyte fragility, Thalassemia, Red Cell, Medicine, Internal medicine, Hematocrit, Hemolysis

Related papers

Related paper 1Related paper 2
Back to paper searchBrowse research topicsOriginal source
[Evaluation of red cell mean corpuscular volume and simple tube red cell osmotic fragility quantitative test in detection of thalassemia]. — Research Paper | ScholarLens