[Determination of C-peptide, serum insulin, and characteristics of tissue insulin resistance in patients with osteoarthrosis].

A hundred and seventy-nine patients with osteoarthrosis (OA) (mean age 50.48+/-5.81 years) were examined for metabolic syndrome (MS) from the International Diabetic Federation (IDF) criteria in the groups with normal and increased fasting C-peptide levels. The blood level of immunoreactive insulin was determined and the insulin resistance indices (Cari, HOMA-IR, ISI, and QUICKI) were calculated. The results were analyzed using the correlation analysis and methods of multivariate statistics. HyperC-peptidemia was found in 84.36% of patients with OA, hyperinsulinemia in 82.12%. As C-peptidemia increased, metabolic disturbances progressed in terms of levels and absolute values. At the same time four fifths of the OA patients with normal laboratory C-peptide levels were diagnosed as having MS from the 2005 IDF criteria. The level of C-peptide and the HOMA-IR and QUICKI indices were more closely correlated with the severity of polyosteoarthritis than insulin. The relationship of insulin resistance to the course of osteoarthritis has been confirmed. It is suggested that hyperC-peptidemia and hyperinsulinemia shows an inflammation-adaptive role in the pathogenesis of OA, the latter associated with obesity in particular.