2006•PubMedRequires access

[Determination of notoginsenoside R1 and ginsenoside Rg1 in Rupixiao tablets by HPLC].

Guobing Xu, Zhengtao Wang, Nie Pan, Zhe Zhao

Abstract

OBJECTIVE: To determine the content of notoginsenoside R1 and ginsenoside Rg1 in Rupixiao tablet by reverse-phase high performance liquid chromatography. METHOD: A Kromacil C18 column was used with a mixture of acetonitrile and 0.05% phosphoric acid solution (20:80) as the mobile phase at a flow rate of 1.2 mL x min(-1) with the detection wavelength at 203 nm. RESULT: The measurement proved to be linear over the range of 0.941-9.41 g for notoginsenoside R1 and 1.04-10.4 g for ginsenoside Rg1. The average recovery of this method was 97.3% and 97.9% respectively. CONCLUSION: The method was simple, reliable, and accurate and can be used for the quality control of this preparation.

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Available abstract

Key concepts: Ginsenoside Rg1, Chromatography, Phosphoric acid, High-performance liquid chromatography, Chemistry, Ginsenoside, Linear range, Acetonitrile