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[Lymphohistiocytic infiltration of endometrial adenocarcinoma].

M. Böhme, M Löttge, Doris Schmidt, I Röse, W Weise, J Morenz

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Abstract

Mononuclear cells adjacent to endometrial adenocarcinoma were evaluated in 8 biopsies by the immunoperoxidase technique. Between benign and malignant tissue a remarkable infiltration of CD45+, CD3+, CD4+, CD8+, and CD14+ cells could be observed. B cells (CD19) and NK cells (CD57) were rare. Tumor-infiltrating lymphocytes were only sparsely distributed. The findings suggest a cellular, yet ineffective, immune reaction of the host against the tumor at the borderline between benign and malignant tissue.

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What this paper is about

Mononuclear cells adjacent to endometrial adenocarcinoma were evaluated in 8 biopsies by the immunoperoxidase technique. Between benign and malignant tissue a remarkable infiltration of CD45+, CD3+, CD4+, CD8+, and CD14+ cells could be observed. B cells (CD19) and NK cells (CD57) were rare. Tumor-infiltrating lymphocytes were only sparsely distributed. The findings suggest a cellular, yet ineffective, immune reaction of the host against the tumor at the borderline between benign and malignant tissue.

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Available abstract

Mononuclear cells adjacent to endometrial adenocarcinoma were evaluated in 8 biopsies by the immunoperoxidase technique. Between benign and malignant tissue a remarkable infiltration of CD45+, CD3+, CD4+, CD8+, and CD14+ cells could be observed. B cells (CD19) and NK cells (CD57) were rare. Tumor-infiltrating lymphocytes were only sparsely distributed. The findings suggest a cellular, yet ineffective, immune reaction of the host against the tumor at the borderline between benign and malignant tissue.

Key concepts: Infiltration (HVAC), Medicine, Pathology, CD3, Adenocarcinoma, CD8, Immunoperoxidase, CD19

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