Effect of Cyclosporin-A on Hepatic and Renal Allograft Mononuclear Cell Infiltration.

Amononuclear cell infiltrate is the dominant histopathologic lesion of the allograft rejection process.1 This infiltrate in renal allografts has been characterized previously by immunofluorescence. It consists predominantly of suppressor/cytotoxic T cells. Furthermore, there is no correlation between the degree of infiltration and the severity of the rejection process.2 Using a new sensitive immunoperoxidase procedure, we quantitated the mononuclear cell infiltrate in hepatic and renal allografts and correlated the severity of the infiltrate with clinical abnormalities resulting from the rejection process.