Clinicopathologic Study of 8 Cases of Primary Cutaneous CD30-positive Cutaneous Large Cell Lymphoma

Background : Although several cases of primary cutaneous CD30-positive large cell lymphoma have been reported, immunotimtochemical study on the tumor has not been reported in Korea. Objective : Our purpose is to evaluate the chmcopathologic and immunohistochemical findings of primary cutaneous CD30-positive large cell lymphoma. Methods : An immumohistochemical study was performed on paraffin sections of 8 primary cutaneous CD30-positive large cell lymphoma using CD3, CD45RO, CD45, CD20, CD30, and epithelial membrane antigen(EMA). Results: 1. Primary cutaneous CD30-positive large cell lymphoma occaned equally on males and females. The average age of the patients was 49. The lesion occurred most commonly as nodules on the extremities. Spontaneous regression occurred in 3 cases. The most common treatment was radiotherapy. 2. Histopathologically, 2 of 8 cases showed epidermal hyperplasia with intraepidermal neutrophils. Epidermotropism was found focally in 1 case. Inflammatory cells were present at the periphery of the lesions in 2 cases, but they were admixed with the large atypical cells in 1 case. Tumor cells invaded the subcutaneous tissue in 4 of 6 cases. 3. Immunohistochemically, the large anaplastic cells showed CD30 positivity. Tumor cells in all cases showed positivity for CD3, CD45RO, and CD45, but negative for CD20. Tumor cells stained with EMA in 1 of 6 cases. Conclusion : Primary cutaneous CD30-positive large cell lymphoma showed immumophenotype of T-cell lymphoma. It showed some clinicopathologic features of lymphomatoid papulosis, which suggests that both entities represent 2 ends(malignant and benign) of a spectrum of CD30-positive lymphoproliferative disorders. Therefore, for the diagnosis of primary cutaneous CD30-positive large cell lymphoma, all clinicopathologic and immunohistochemical findings should be considered together.