Primary Cutaneous CD30-negative Large T-cell Lymphoma

Primary cutaneous CD30-negative large T-cell lymphoma without prior or concurrent mycosis fungoides represents a distinct group of cutaneous T-cell lymphoma with an aggressive clinical behavior. Primary cutaneous CD30-negative large T-cell lymphoma is a rare disorder which represents only about 5% of primary cutaneous T-cell lymphoma. A 51-year-old woman presented with a rapid growing, ulcerative plaque on the right lower leg of 2 years duration. Histologically, it showed diffuse infiltrates with a predominance of medium-sized to large pleomorphic lymphocytes in the dermis and subcutaneous fat layers, which stained positively with CD3 and negatively with CD20, CD30, CD56 on immunohistochemical staining. There was no evidence of extracutaneous metastsis.