2003•PubMedRequires access

[Study of NMDAR expression in hippocampal CA(1) region in neonatal rats with hypoxic-ischemia].

Cao Yh, L Wang, Yu-Hong Cao, Bao-Xi Wang, Sui-He Yu

Abstract

AIM: To study the expressions of NMDAR in hippocampal CA(1) region after hypoxic-ischemic brain damage(HIBD) in neonatal rats. METHODS: An neonatal rat model with hypoxic-ischemic brain damage was set up. The expression of NMDAR was detected in normal control and hypoxic-ischemic (HI) brain damage group by immunohistochemical staining and in situs hybridization. RESULTS: The number of NR1(+) and NR1 mRNA(+) cells decreased slightly in hippocampal CA(1) region at 2 h after HI. The numbers increased from 24 h to 48 h after HI, and reached maximum at 72 h after HI. CONCLUSION: NR1 expressed in hippocampal CA(1) region of normal neonatal rats, and the expression is up-regulated after HI brain injury.

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Key concepts: Hippocampal formation, Brain damage, Immunohistochemistry, Ischemia, NMDA receptor, Hypoxia (environmental), In situ hybridization, Hippocampus