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Effect of gangliosides on N-methy-D-aspartate receptor expression in hippocampal CA_1 in neonatal rat models with cerebral hy-poxic-ischemia

Hui Yanping

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Abstract

Objective To study the expression of N-methy-D-aspartate receptor(NMDAR) and NMDAR mRNA in hip-pocampal CA1 and the effect of monosialotetrahexosylganglioside(GM1) on the expression after hypoxic-ischemic brain damage(HIBD) in neonatal rats. Methods An animal model of neonatal hypoxic-ischemic brain damage was established. The expression of NR1 positive cells was detected with NR1 immunohistochemisry and NR1 mRNA in situs hybridization. Results The expression of positive cells was observed in hippocampal CA1 in neonatal rats NR1 positive cells and NR1 mRNA positive cells were increased in hippocampal CA1 area after hypoxic-ischemia (HI). The expression of NR1 and NR1 mRNA was down-regulated after GM1 administration in GM1 group compared to that of HI group. Conclusion GM1, as antagonist of the NMDAR, plays a role in brain protection against hypoxic-ischemia.

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What this paper is about

Objective To study the expression of N-methy-D-aspartate receptor(NMDAR) and NMDAR mRNA in hip-pocampal CA1 and the effect of monosialotetrahexosylganglioside(GM1) on the expression after hypoxic-ischemic brain damage(HIBD) in neonatal rats. Methods An animal model of neonatal hypoxic-ischemic brain damage was established. The expression of NR1 positive cells was detected with NR1 immunohistochemisry and NR1 mRNA in situs hybridization. Results The expression of positive cells was observed in hippocampal CA1 in neonatal rats NR1 positive cells and NR1 mRNA positive cells were increased in hippocampal CA1 area after hypoxic-ischemia (HI). The expression of NR1 and NR1 mRNA was down-regulated after GM1 administration in GM1 group compared to that of HI group. Conclusion GM1, as antagonist of the NMDAR, plays a role in brain protection against hypoxic-ischemia.

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Available abstract

Objective To study the expression of N-methy-D-aspartate receptor(NMDAR) and NMDAR mRNA in hip-pocampal CA1 and the effect of monosialotetrahexosylganglioside(GM1) on the expression after hypoxic-ischemic brain damage(HIBD) in neonatal rats. Methods An animal model of neonatal hypoxic-ischemic brain damage was established. The expression of NR1 positive cells was detected with NR1 immunohistochemisry and NR1 mRNA in situs hybridization. Results The expression of positive cells was observed in hippocampal CA1 in neonatal rats NR1 positive cells and NR1 mRNA positive cells were increased in hippocampal CA1 area after hypoxic-ischemia (HI). The expression of NR1 and NR1 mRNA was down-regulated after GM1 administration in GM1 group compared to that of HI group. Conclusion GM1, as antagonist of the NMDAR, plays a role in brain protection against hypoxic-ischemia.

Key concepts: Hippocampal formation, Ischemia, NMDA receptor, Messenger RNA, Receptor, Antagonist, Hypoxia (environmental), Brain damage

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Effect of gangliosides on N-methy-D-aspartate receptor expression in hippocampal CA_1 in neonatal rat models with cerebral hy-poxic-ischemia — Research Paper | ScholarLens