2003•Di-Si Junyi Daxue xuebaoRequires access

Effect of GM_1 on HSP70 expression and pathologic damage in hippocampal CA_1 in neonatal rat model of hypoxic-ischemia

Yan Cao

Abstract

AIM: To study the expression of HSP70 and pathologic damage in hippocampal CA 1 after hypoxic ischemic brain damage(HIBD)in neonatal rats and the effect of monosialotetrahexosylganglioside(GM 1)on it . METHODS: Animal models of neonatal hypoxic ischemic brain damage were set up.We investigated the expression of HSP70 with immunohistochemistry and pathologic changes with HE stain ing. RESULTS: The expression of HSP70 was hardly observed in hippocampal CA 1 after HI in neonatal rats. Neurons in hippocampal CA 1 showed severe ischemic damage. The expression of HSP70 and the pathologic changes had more remarkable improvement after GM 1 administration in GM 1 group than that in HI group. CONCLUSION: GM 1 could improve the expression of HSP70 protein and reduce HIBD pathologic injury; GM 1 has the effect of brain protection against hypoxic ischemia.

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Key concepts: Hippocampal formation, Brain damage, Hsp70, Immunohistochemistry, Ischemia, Neuronal damage, Medicine, Pathology