2005•PubMedRequires access
[Pharmacokinetics of breviscapine in dogs and rabbits following single intravenous administration].
Qingfei Liu, Guoan Luo, Yiming Wang, Yuhui Ma, Rongli Zhang
Open publisher page 2 citations
Abstract
OBJECTIVE: To study pharmacokinetics of breviscapine in dogs and rabbits after iv. single dose. METHODS: Lc/Lc extract was used to prepare test samples and HPLC was used to determine breviscapine. RESULTS: Breviscaplin was fitted to double-department model in dogs and rabbits after iv. single dose. The main parameters in dogs were: A = 56.93 +/- 23.14, B = 1.61 +/- 1.11, alpha = 0.2328 +/- 0.1321 min, beta = 0.0255 +/- 0.0187 min(-1), t(1/2alpha) = 2.98 +/- 1.42 min, t(1/2beta) = 27.14 +/- 14.35 min, K21 = 0.10312 +/- 0.0112 min(-1), K10 = 0.1904 +/- 0.1319 min(-1), K12 = 0.0367 +/- 0.0306 min(-1), CL = 39.41 +/- 20.44 ml x min(-1), AUC = 3074 +/- 1055 mg x min x L(-1), respectively. The main parameters in rabbits were:A = 2.64 +/- 1.12, B = 0.28 +/- 0.12, alpha = 0.1439 +/- 0.0681 min(-1), beta = 0.0162 +/- 0.0456 min(-1), t1/2alpha = 4.82 +/- 1.65 min, th1/2beta = 42.66 +/- 18.77 min, K21 = 0.0285 +/- 0.0147 min(-1), K10 = 0.0820 +/- 0.00378 min(-1), K12 = 0.0496 +/- 0.0241 min, CL = 337.05 +/- 156.48ml x min(-1), AUC = 356 +/- 114 mg x min x L(-1), respectively. CONCLUSION: Breviscapine has short half-life after intravenous administration to dogs and rabbits,which show breviscapine is eliminated rapidly and has short action time.