The pharmacokinetics of Xiangbei injection after intravenous administration in SD-rats by HPLC-MS assays

OBJECTIVE To study the pharmacokinetics of Xiangbei injection after intravenous administration in SD rats. METHODS The concentrations of 4,5-dimethoxy-canthin-one in Xiangbei injection were determined by HPLC-MS assays. RESULTS The kinetic process of Xiangbei injection in SD-rats was best fitted to two-compartment models.At the doses of 2.5 mL·kg-1 and 10 mL·kg-1 in rats,the t 1/2α values were 0.58 min and 0.44 min,t1/2β were 6.64 min and 7.06 min;AUC were 192.24 μg·L-1·min-1 and 1 060.73 μg·L-1·min-1;CL were 18.21 mL·min-1 and 13.20 mL·min-1,respectively. CONCLUSION Xiangbei was quickly distributed in rats after i.v.and the concentration decreased rapidly.