Effect of low-dose estrogen combined with progestogen on menopause-related indexes and quality of life in postmenopausal women

Objective:To explore the effect of hormone replacement therapy(HRT) on menopause-related indexes and quality of life in postmenopausal women.Methods:A total of 60 postmenopausal women were divided into treatment group and control group from January 2005 to September 2011,30 women in each group,the postmenopausal women in the two group were treated with dietary therapy and physical exercise;the women in treatment group were treated with oral administration of premarin,0.625 mg per day,28 days were one course of treatment;from the 19th day to the 28th day during every course of treatment,they were treated with medroxyprogesterone acetate for three courses of treatment.The remission conditions,the changes of various hormones and biological markers in the two groups were observed.Results:The clinical symptoms after treatment in treatment group were improved significantly,the levels of estradiol and progestogen increased obviously,the contents of follicle stimulating hormone(FSH),luteinizing hormone(LH),alkaline phosphatase(AKP),total cholesterol(TC),and triglyceride(TG) decreased significantly,compared with those before treatment in treatment group and after treatment in control group,there was statistically significant difference(P0.01,P0.05).Conclusion:Low-dose estrogen combined with progestogen can improve the levels of hormone-related indexes and clinical symptoms of postmenopausal women,improve the quality of life,and the method is worthy to be applied and spread in clinic.