Effects of percutaneous coronary intervention therapy on platelet activation and inflammatory factors in elderly patients of acute coronary syndrome

Objective To study the effects of percutaneous coronary intervention(PCI) therapy on platelet activation and inflammatory factors in elderly patients with acute coronary syndrome(ACS). Methods Sixty-eight elderly ACS patients with PCI therapy and 44 healthy controls were enrolled.Fasting venous blood were collected to determine the expression of CD62P,receptor complex of glucose protein Ⅱb/Ⅲa(GPⅡb/Ⅲa),plasma fibrinogen(Fg) and serum high-sensitivity C-reactive protein(hs-CRP) befor PCI and 1st,7th and 28th morning after PCI. Results Significant increase of CD62P,GPⅡb/Ⅲa,Fg and hs-CRP were revealed in ACS patients than those in the controls(P0.05).However,there was no significant difference in these parameters among patients with different Gensini scores(P0.05). Conclusion PCI can activate the platelet and inflammatory reaction.Therefore,antiplatelet and antithrombotic management,especially within 4 weeks after PCI,is critical for prevention of coronal thrombosis and restenosis. WT5HZ〗