Effect of percutaneous coronary intervention on inflammatory reactions and platelet activation in patients with acute coronary syndrome

Objective: To observe the changes of serum level of inflammatory mediators IL-6,hsCRP and platelet activity index CD62p,CD63 before and after percutaneous coronary intervention(PCI) in patients with acute coronary syndrome(ACS).Methods: The blood was collected respectively at 30 min before PCI and 2,24,72,96 h after PCI in 58 patients with ACS and control group.The serum levels of the CD62p,CD63 were assayed by flow cytometry,the hs-CRP was measured by immune scatter turbidimetry and IL-6 was analyzed by enzyme linked immunosorbent assay(ELISA).Results: The IL-6,hs-CRP,CD62p,CD63 levels in the patients with ACS increased significantly compared with control group(P0.05),and those indices at 2,24 and 72 h group increased significantly compared with pre-PCI group(P0.05).Those indices peaked at 24 h after PCI,declined at 72 h after PCI,and recovered to pre-PCI level at 96 h(P0.05).Conclusion: Platelet activation and inflammatory reactions play an important role in the occurrence and development of ACS.PCI may activate platelet activation and inflammatory reactions factors in patients with ACS.