Analysis on the results of prenatal screening during the first trimester of pregnancy in 2 698 cases

Objective: To explore the availability and feasibility of prenatal screening for Down's syndrome during the first trimester of pregnancy in Ji'nan region. Methods: Time- resolved fluorescence method was applied to evaluate serum PAPP- A,free β- HCG and nuchal translucency(NT) by time- resolved fluoroimmunoassay in 2 698 cases during 9- 13+ 6gestational weeks,and the results combined with age,gestational weeks,and weight of the pregnant women,were input into the prenatal screening software assessment system made by Finland. The risks of the target diseases were evaluated,and prenatal diagnosis was carried out for the high risk population. Results: A total of 108 cases were diagnosed as high risk population of target diseases in 2 698 pregnant women,and the positive rate was 4%. Among them, 67 cases accepted fluffy prenatal diagnosis,30 cases accepted amniotic fluid prenatal diagnosis,4 cases with Down's syndrome were diagnosed. One case with trisomy 18 was checked,2 cases with other chromosomal abnormalities were diagnosed. During follow- up,children of misdiagnosis were not found,but 16 cases with other fetal abnormalities were found,including 6 cases with fetal multiple malformations,3 cases of stillbirth,5 cases with fetal hydrops,1 case with polycystic kidney,1 case with cleft lip and palate. Conclusion: Prenatal screening of serum markers combined with nuchal translucency during the first trimester of pregnancy has practical application value for effectively preventing children born with target diseases,and it will be ahead of prenatal diagnosis time greatly,reduce the damage for odinopoeia along with increasing weeks of gestation and alleviate mental burden of the pregnant women.