Analysis on the results of prenatal screening during the fi rst trimester of pregnancy

Objective:To explore the availability and feasibility of prenatal screening during the first trimester of pregnancy in reducing birth defects. Methods:Time resolved fluorescence method was applied to evaluate serum PAPP-A,free-h CGbβand nuchal translucency(NT)in 909 cases during 9-14 gestational weeks,and the results combined with age,weight and gestational weeks of the pregnant women,using Life Cycle3.2 evaluation software,the risks of the fetus with Down syndrome and Edward syndrome were evaluated,and prenatal diagnosis was carried out for the high risk population. Results:A total of 47 cases were diagnosed as high risk population of target diseases in 909 pregnant women,and the positive rate of screening was 5.17%. Among them,high risk pregnant women accepted fluffy prenatal diagnosis,5 cases of abnormal karyotype were confirmed,the positive predictive rate was 10.6%. Including 3 cases with Down syndrome were checked,one case with Edward syndrome were diagnosedm,one case with Turner syndrome were confirmed. Conclusion:It effectively that prenatal screening during the first trimester of pregnancy can screen out the chromosomal abnormalities fetus.