Clinical Value of Prenatal Screen for Down's Syndrome and Prenatal Diagnosis in the First and Second Trimester in Xiangtan

Objective To explore the clinical value of prenatal screen and diagnosis in the first and second trimester for preventing birth defects.Methods The serum markers of 18247 cases of pregnant women were detected by automatic Time-Resolved Fluorescence(TRF),and amniotic fluid culture test for fetal karyotype diagnosis in high-risk pregnant women were carried out.Results In the 18247 cases of pregnant women,the high risk of DS and trisomy 18 were 873 and 91 cases respectively.The high risk of NTD was 104 cases,and the total positive rate was 5.85%.In the 583 cases of pregnant women who accepted the amniotic fluid culture for prenatal diagnosis,the definitive diagnosis of chromosome numerical aberration were 19 cases in which included 13 cases of DS,2 cases of trisomy and 4 cases of sex chromosomal abnormalities.The chromosomal structural abnormality were 13 cases and spina bifida or anencephaly were 13 cases,which was diagnosed by type-B ultrasonic.Conclusion Prenatal screen and diagnosis are effective predictors for adverse pregnancy outcome and have significant clinical value to prevent congenital defects in infants.