Effect of Simo decoction on gastrointestinal function and Gastrin in binding-cold stressed mice

Objective To explore the mechanism of Simo decoction on gastrointestinal functional disorder. Methods Forty-five mice were randomly divided into 3 groups:normal group,Simo decoction group and model group. The models of gastrointestinal dysfunction were induced with physical factor like binding,hot and cold. After 14 days administration,the change of mice's weight were observed,the functions of gastric emptying and small intestinal propulsion induced by semisolid nutrient medium and the gastrin of blood serum were detected with RIA. Results The mouse weight in Simo decoction group significantly increased compared with the model group (P0.01); the gastric emptying and small intestinal motility and gastrin levels in Simo decoction group were lowered compared with the model group(P0.05),was not significant compared with normal group(P0.05). Conclusion Simo decoction can restrain gastrointestinal motility and the release of endogenous gastrin to irritable gastrointestinal dysfunction,which is the mechanism to treatsthenic gastrointestinal dysfunction maybe.