Effects of compound Xiaojingtong capsule on MDA,NO,SOD,GSH-PX in blood serum and uterus tissue of rats with dysmenorrhea induced by oxytocin

Objective To investigate the protective effect of compound Xiaojingtong capsule(CXJTC) on oxytocin-induced dysmenorrhea in rats.Methods Sixty rats were randomly divided into control group,dysmenorrhea model group,high-dose(2.0g/kg),middle-dose(1.0g/kg) and low-dose(0.5g/kg) CXJTC groups,and Tianqi Tongjing capsule(TQTJC) group(2.0g/kg).Diethylstilbestrol was continuously administrated by subcutaneous injection,once a day for 10 days in rats of all groups except for the rats in control group.CXJTC was administrated by intragastric mode for 7 days in rats of all CXJTC groups and distillated water was instead for the rats in model group.The administration of oxytocin(0.2U) was carried on in every rat at 40 min after last administration.The rats were anesthetized at one hour after administration of oxytocin.The blood was taken and the uterus was dissected and homogenated for measurement of concentration of NO and MDA,and the activities of SOD and GSH-PX in serum and homogenate of uterus were detected.Results As compared with those in model group,the activities of SOD and GSH-PX were obviously increased,and the concentration of NO was increased too,however,the concentration of MDA was decreased in serum and homogenate of uterus in CXJTC group.Conclusion CXJTC has a protective effect on rats with dysmenorrhea induced by oxytocin,and the effects may be caused by increasing the concentration of NO,and the activities of SOD and GSH-PX,and by decreasing the concentration of MDA.