Effect of Vitamin E on serum T-SOD and GSH-PX and apoptosis of gardiacmuscle cells in ovariectomized rats

Objective To discuss the protective function and the mechanism of VE on the cardiac muscle cells of the ovariectomized rats,using ovariectomized rats as climacteric period animal model.Methods The contrast group was the normal adult rats and the ovariectomized rats injected into plant oil:aged group and sham operation group,the experiment group was the rats extirpated ovaries who were injected VE in its′ abdomen:5 mg/kg,15 mg/kg,VE was injected into the experiment group for continuous 9 weeks.T-SOD,GSH-PX and Hoechst were determined by the colorimetric method.Results Compared with the negative control group,the activity of T-SOD in serum were up regulated,but lower than sham operation group;High Vitamin E could increase the activity of T-SOD in ovariectomized group,large dose group could improve the activity of GSH-PX more obviously than small dose group,but the effect was lower than sham operation group.Conclusion High Vitamin E could increase T-SOD and GSH-PX activity and decrease MDA content,improve expression of Bcl-2.It could also restrain the death of menopause rats′ cardiac muscle cells.High Vitamin E could improve the ability of anti oxidation,it could delay aging for the myocardial cells of post menopausal women.