Comparision of Therapeutic Effects and Cost - effectiveness Analysis of Foscarnet and a - interferon for Chronic Hepatitis B

OBJECTIVE: To compare the clinical and economical effects of foscarnet and a - interferon in treating chronic hepatitis B. METHODS: 90 cases were randomly divided into two groups. Group A, foscarnet in a dose of 2.4g,i. v . ,b .i .d . for 1 month.Group B, α - interferon in a dose of 3 million units, im, q.d. for 3 months.The clinical effects were observed and evaluated with pharmacoeconomic cost - effectiveness analysis.RESULTS: In improving symptoms and liver function, two therapeutic regimes presented similar effect.But lower expenses were costed in unit effect of decreasing ALT in group B.In clearance of virus index, group A showed better effects and costed lower expenses in unit effect of HBeAg negative conversion .CONCLUSION; Both foscarnet and a - interferon presented fairly good therapeutic effect for chronic hepatitis B.In improving liver functions, two preparations showed similar clinical effect but α - interferon presented better economical effect .In antiviral efficacy, foscarnet showed better clinical and economical effects.