Treatment of Diabetic Nephropathy with Vincristine in Rat Model

Objective To verify the curative effect of vincristine (VCR) on diabetic nephropathy in rat model. Methods Establish the rat model of diabetic nephropathy by induction with streptozotocin (STZ) . Divide the rats into test and control groups. The rats in test group were injected i. v. with VCR twice a week at a dosage of 0.2 mg/kg body weight, and those in control group were untreated. Observe the blood sugar and urinary protein levels, renal function, the ratio of kidney weight to bodyweight, as well as the pathological changes of kidneys of the rats in test group and compare with those in control group. Results The urinary protein levels of rats in test group were significantly decreased, and the ratios of kidney weight to bodyweight were significantly lower than those in control group. Under optical microscope, the pathological change of kidney in test group was also improved. Conclusion Vincristine is effective in decreasing urinary protein level and improving the pathological change of kidney at early stage of diabetic nephropathy.