Clinical observation on Houpu Paiqi mixture in treatment of senile patients with obstinate constipation

OBJECTIVE To investigate the therapeutic effect of Houpupaiqi mixture in senile patients with obstinate constipation. METHODS 116 senile patients with obstinate constipation were randomly divided into 2 groups as following: Houpupaiqi mixture group (n=60) and macrogol 4000 group (n=56). The Houpupaiqi mixture group was given Houpupaiqi mixture 50mL bid, the macrogol 4000 group was given macrogol 4000 10 g tid. Continuously treated with 2 weeks, patients' defecation was recorded respectively. The adverse reactions were observed. RESULTS After treated for 2 weeks, the number of patients whose stool recovered to the normal state in the Houpupaiqi mixture group and the macrogol 4000 group was 93.4% and 70.4% respectively, there was statistically significant difference. The total effective rate in the Houpupaiqi mixture group was 96.7%,while that in the macrogol 4000 group was 74.1% (P0.05). CONCLUSION The clinical experiment shows that Houpupaiqi mixture is safe and effective in treating senile patients with obstinate constipation, the therapeutic effects is superior than macrogol 4000.