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Study on Diagnostic Significance of Hepatic Fibrosis Histology Staging by Examing the Levels of Serum Markers

Zhijun Zhao

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Abstract

Objective To Study The relationship between the serum markers with liver fibrosis in chronic hepatitis B and changes in liver histology. Methods The serum levels of hyaluronic acid (HA),procollagen type Ⅲ(PCⅢ),laminin(LN),typeⅣ procollagen (IV.C) and transforming growth factor β1(TGF-β1) were measured by RIA Kit in patient with chronic hepatitis B. At the same time ,liver biopsy was performed.Results The serum levels of above five markers increased with hepatitis and fibrosis progression . The relationship between the serum levels of PC Ⅲ with hepatitis was close,both HA and TGF-β1 was closely related to fibrosis.Conclusion The combinated assay of serum levels of above five markers can identify pathological stages of hepatic fibrosis and hepatitis .

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What this paper is about

Objective To Study The relationship between the serum markers with liver fibrosis in chronic hepatitis B and changes in liver histology. Methods The serum levels of hyaluronic acid (HA),procollagen type Ⅲ(PCⅢ),laminin(LN),typeⅣ procollagen (IV.C) and transforming growth factor β1(TGF-β1) were measured by RIA Kit in patient with chronic hepatitis B. At the same time ,liver biopsy was performed.Results The serum levels of above five markers increased with hepatitis and fibrosis progression . The relationship between the serum levels of PC Ⅲ with hepatitis was close,both HA and TGF-β1 was closely related to fibrosis.Conclusion The combinated assay of serum levels of above five markers can identify pathological stages of hepatic fibrosis and hepatitis .

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Available abstract

Objective To Study The relationship between the serum markers with liver fibrosis in chronic hepatitis B and changes in liver histology. Methods The serum levels of hyaluronic acid (HA),procollagen type Ⅲ(PCⅢ),laminin(LN),typeⅣ procollagen (IV.C) and transforming growth factor β1(TGF-β1) were measured by RIA Kit in patient with chronic hepatitis B. At the same time ,liver biopsy was performed.Results The serum levels of above five markers increased with hepatitis and fibrosis progression . The relationship between the serum levels of PC Ⅲ with hepatitis was close,both HA and TGF-β1 was closely related to fibrosis.Conclusion The combinated assay of serum levels of above five markers can identify pathological stages of hepatic fibrosis and hepatitis .

Key concepts: Procollagen peptidase, Medicine, Fibrosis, Histology, Liver biopsy, Hepatic fibrosis, Pathology, Hyaluronic acid

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Study on Diagnostic Significance of Hepatic Fibrosis Histology Staging by Examing the Levels of Serum Markers — Research Paper | ScholarLens