2007•Chinese journal of integrated traditional and Western medicineRequires access
Relationship between serum biochemical markers and hepatic fibrosis in patients with chronic hepatitis B
Zhou Wen-hon
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Abstract
Objective:To study the relationship between serum biochemical markers and hepatic fibrosis in patients with chronic hepatitis B.Methods:A total of 177 patients with chronic hepatitis B was enrolled in this study.The level of serum ALT,AST,ALP,TBil,Alb,Glo and serum fibrosis markers HA,LN,PCⅢ,CⅣ were detected.And the liver histological changes were studied.The relationship between the serum biochemical markers and hepatic fibrosis were analyzed.Results:The level of some serum biochemical markers Alb,Glo,HA,PCⅢ,CⅣ were correlated with the hepatic fibrosis stage,and the correlation coefficient(r) were-0.299,0.282,0.595,0.387,and 0.480 respectively.With the incresaing severity of hepatic fibrosis,the level of albumin decreased,and the level of Glo,HA,PCⅢ,CⅣ ascended.Conclusion:The serum biochemical markers can at least partly reflect the pathological degree of hepatic fibrosis in patients with chronic hepatitis B.It is useful in diagnosis of hepatic fibrosis in the hospital,which cannot develop liver biopsy.