2001•Journal of Nantong MedicalRequires access

CLINICO-PATHOLOGICAL SIGNFICANCE OF MICROVESSEL DENSITY AND F-VIII EXPRESSION IN GASTRIC CANCER

Hua Huang

Abstract

Objective:To evulate the clinico-pathological signgnificance of intratumoral microvessel density(MVD) and F-Ⅷ expression in gastric cancer. Methods:MVD in 56 speciments resected from patients with gastric cancer was investigated by immunohistochemical staining with a monoclonal antibody against F-Ⅷ related antigen.Results:The means MVD was 40.24±13.6 in tumor , 25.20±10.12 in tumor-adjacent and 14.21±4.25 in normal tissue(P0.05).The MVD in patients with cancer metastasis 40.17±8.91 which was significantly greater than in patients without cancer metastasis was 19.21±10.04(P0.01 ).Conclusion:MVD was related to lymph node metastasis and bematogenous dissemination of gastric cancer.Beside lymph node metastasis, depth of invasion ,stage of tumor,MVD was also of prognostic significance. [

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Key concepts: Immunohistochemistry, Medicine, Cancer, Pathological, Pathology, Stage (stratigraphy), Metastasis, Lymph