Effect of microvessel density in mesenchyme on the tumor biological behavior in gastric carcinoma

Objective:In order to explore the relationship between microvessel density (MVD) and clinical pathological characteristics in gastric carcinoma. Methods:The present study has been carried out in 74 cases of gastric carcinoma and 17 cases of corresponding non tumor normal gastric tissue obtained from clinical operation by the method of immunohistochemistry to investigate the MVD. Results: The density of tumor stromal microvessels was higher than that of corresponding non tumor normal gastric tissue ( P 0.01) . There were positive relationship between MVD and lymph node metastasis, tumor invasive ability. The MVD was strongly increased in the case of lymph node metastasis and under the muscular layer invaded( P 0.05). Conclusion: MVD is a significant marker to prognosticate growth ,invasion and metastasis of gastric carcinoma.