2007•Chinese Journal of Laboratory DiagnosisRequires access
Radioimmunoimaging of ~(153)Sm labeled anti-CEA monoclonal antibody in nude mice bearing human colon carcinoma
Hui‐Jing Li
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Abstract
Objective To study radioimmunoimaging of 153 Sm labeled anti-CEA monoclonal antibody and normal mice IgG in mude mice bearing human colon carcinoma and provide the basis for clinical use.Methods 7.4MBg/0.1ml labeled antibody were injected into the tail vein in each respectively.SPECT were measured after 2、4、8、24 h interval of injection.Percent injected dosage of every gram tissue(%ID/g)were measured after 4、8、24 h interval to death.Results 153Sm-CEA can selective concentrate in tumor tissue,which the rate of ingestion was higher than 153 Sm-IgG(P0.05).Conclusion 153Sm-CEA had affinity to colon carcinoma which over expressed CEA in nude bearing human colon carcinoma.153S m-CEA is prospective to be use as the direct Carrier of colon Carcinoma diagnosis.