Radioimmunoimaging of ~(153)Sm labeled anti-AFP monoclonal antibody in nude mice bearing human primary hepatic carcinoma

Objective To study radioimmunoimaging of ~(153)Sm labeled anti-AFP monodonal antibody and normal mice IgG in mude mice bearing human primary hepatic carcinoma and provide the basis for clinical use.Methods 7.4 MBg/0.1 ml labeled antibody were injected into the tail vein in each respectively.SPECT were measured after 2、4、8、24 h interval of injecion.Percent injected dosage of every gram tissue(%ID/g)were measured after 4、8、24 h interval to death.Results ~(153)Sm-AFP can selective concentrate in tumor tissue,which the rate of ingestion was higher than~(153)Sm-IgG(P0.05).Conclusion ~(153)Sm-AFP had affinity to hepatic carcinoma which over expressed AFP in nude bearing human hepatic carcinoma.~(153)Sm-AFP is prospective to be use as the direct Carrier of hepatic Carcinoma diagnosis.