Research of drug-loaded calcium alginate/chitosan microcapsules

The calcium alginate microbeads with a mean size of 820nm were prepared by emulsification process at the first place,then the chitosan/calcium alginate microcapsules were produced by coating chitosan on the microbeads.Using trypsin as a model drug,trypsin-loaded chitosan/calcium alginate microcapsules were obtained through a two-step method,and the influences of different concentrations of drug,different molecular weight and concentrations of chitosan,different membrane forming time on the drug load were investigated.The results show that the chitosan/calcium alginate microcapsules could be potential carrier for loading trypsin.